Plenity vs Alli: Which is Better for Weight Loss?
If you’ve been trying to lose weight with no success, you’ve probably thought about buying a fat burner/weight loss supplement to see better results.
There is no denying that weight loss is not an easy task; more so if you’re prone to weight gain genetically. There are a lot of people out there who can eat a seemingly endless amount of food without gaining a pound. Suppose you don’t belong to this group of “lucky” people. In that case, you’ll want to take advantage of natural supplements that boost your metabolism to burn more calories and suppress appetite so you consume fewer calories.
Plenity and Alli are some of the more well-known choices regarding weight loss. Today, we’re going to look at which one of the two is the more effective and healthier option for long-term weight loss, as well as how they compare to the leading weight loss supplements on the natural market.
Plenity vs Alli Summary
Between Plenity and Alli, Alli is definitely the more effective option for short-term weight loss. Alli is a pharmaceutical drug that works by blocking the absorption of calorie-dense fats in your intestines, which helps you lose weight. On the other hand, Plenity contains natural ingredients such as cellulose and citric acid which, although said to help you do a similar thing as Alli, aren’t proven by enough robust studies for us to say that really is the case. While Plenity is a safer option (less likely to cause side effects), you’re unlikely to notice major results (despite what the great marketing and FDA-related claims would make you believe). That said, if you want to lose weight in a healthy way, we recommend doing more research before getting either of these two.
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Plenity vs Alli Overview
Plenity Overview
Plenity is an FDA-cleared weight loss pill from Gelesis. It is intended for people who are obese with a BMI of 25-40kg/m.
The way Plenity works is by making you feel fuller as well as contributing to increased calorie expenditure. This is thanks to the ingredients inside which include cellulose and citric acid.
Plenity costs a whopping $98 for a month’s supply, so many people will be asking if it is worth trying.
There are also some reports of side effects such as diarrhea and nausea, so there are definitely some pros and cons to be weighed against each other. We’ll have a closer look below.
Alli Overview
Alli is a brand name for a pharmaceutical drug orlistat. While orlistat is ordinarily a prescription drug, Alli is available over-the-counter (OTC) since it contains half of the prescription dosage of orlistat.
As we mentioned, Alli works by blocking the absorption of fat in your intestines. Since fat is the most calorie dense of all the macronutrients (9kcal per 1g), you will be able to eat the same amount of food as before but your body will be absorbing about 25% less of it with Alli. As a result, you may notice some degree of weight loss over time.
The only issue with Alli is that it may not be the healthiest option for long-term weight loss. And once you stop using it, there is a possibility that you may regain the lost weight. This is one of the reasons why we’re not the biggest fans of Alli. Still, for some people, Alli can be a really helpful tool.
Let’s have a closer look at how Alli will work for you and how it compares to Plenity.
Plenity vs Alli Ingredients
As mentioned, Plenity contains two active ingredients: cellulose and citric acid.
Cellulose is a type of plant fiber that is said to swell in your stomach once ingested. When in contact with water, cellulose expands to multiple times its size, which the manufacturer claims results in suppressed appetite.
Meanwhile, the citric acid works to boost the metabolism so you burn additional calories.
This two-pronged approach sounds ideal in theory, but how effective is Plenity really?
The answer is that there are not too many human studies on the effectiveness of Plenity’s ingredients. Some of them are industry-funded, as well. As a result, the credibility is questionable.
As for Alli, it contains the synthetic drug Orlistat as its only active ingredient. As we’ve repeated, Orlistat is a weight loss drug that blocks your body from absorbing some of the fat you ingest, which makes it easier to lose weight. The effectiveness of Orlistat is well-studied and it appears to be a reliable drug for weight loss.
Which Formula Looks Better Overall?
Compared to Plenity’s ingredients, Alli is better-researched and more effective overall. In other words, Alli is more likely to give you noticeable results than Plenity.
Now, whether Alli is the safest weight loss option out there is another story. When you factor in the effectiveness, the evidence behind the ingredients, safety, and overall value for money, there are definitely better weight loss supplements on the market than Plenity and Alli.
What do Others Say?

Independent and impartial reviews of Plenity are difficult to find as the product is only available on its website and through a prescription.
As for Alli, it is positively received by the majority of its users. There are some complaints about side effects, mostly related to gastrointestinal issues such as indigestion, bloating, and gas.
Plenity vs Alli Side Effects: Which is Safer?
While there is a small risk of side effects from Plenity, it is a safer option than Alli as it contains natural ingredients that don’t cause adverse reactions in most people. Alli’s side effects are likely to be more frequent and more severe as it is a synthetic drug.
Pricing & Value
Plenity costs $98 per bottle (month’s supply). Alli’s price starts at $57 but it can vary depending on where you buy it and whether there are any discounts currently running.
Takeaway
Alli and Plenity are both well-known weight loss pills, but which one is better?
If you’re looking for the more effective option that will give you faster results, Alli is definitely the better option. Its active ingredient is better-researched than those in Plenity, and the results show.
However, Plenity is the safer option of the two as its ingredients are less likely to cause negative side effects.
In our opinion, neither is the best option on the market. With some research, you can find healthier and just as effective fat burner supplements on offer today
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